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25,26 importantly, it has been reported that minocycline has potent inhibitory effects on both mmp-9 gene expression and proteolytic activity.
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on the other hand, minocycline-treated non tg mice showed increased nfkb and ikb levels.
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in this particular study, researchers investigated whether minocycline would reduce neonatal immune activation that causes hpa dysregulation, and ultimately depression, at a later point an animal s mouse s lifetime.
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